In depression studies of mice, researchers literally throw them into a water tank and observe them swimming. Healthy mice meet the challenge and swim. Depressed mice may swim at first but they will soon wear out and the only movements they will make in that tank of water are the minimal movements necessary to keep their heads above water.
A 2004 study of the magnesium-depression link used the swim test to test the effect of magnesium depletion on depression and anxiety. They fed one group of mice a magnesium-depleted diet for a few weeks and fed control mice a regular diet. At the end of the study period, the poor magnesium deficient mice were prone to anxiety and to depression.

A bad depressive cycle is all about keeping your head above water. On bad days it is often all you can do to survive the day doing only the minimal activity required. Forget about outings, forget about shopping, forget about moving the garden hose. Survive the day. Keep your head above water. When the day is over and you have not drowned, it was a "win." You survived.
Mice and rats must be a lot like humans. Their ability to fit in the smallest crack in my kitchen cabinets aside, when mice are depressed, all they can do is keep their heads above water on those bad days.
To decrease the number of your bad days and increase the time between those down cycles, make sure you have plenty of magnesium in your diet. You can do this two ways (and taking both approaches is not a bad idea):
1) Take a daily magnesium supplement of 3-4.5 mg for every pound of your body weight (6-8 mg/kg) if you do not have a high-magnesium diet. Most of us, by the way, do not consume the RDA/DRI of magnesium.
2) Eat more magnesium-rich foods. The USDA calculates that the food in the figure above are your best bets for magnesium. Lots of vegetables, ideally heirloom varieties, are a very good bet for improving your magnesium levels and for getting all of the other benefits from the world of vegetables.
Improving your magnesium levels will likely alleviate your depression if you are deficient in magnesium. It will certainly help your overall health.
The book, Rebuild from Depression, reviews the top seven nutrient deficiencies associated with depression. It reviews how to identify a deficiency, the best form of supplementation, and the best food sources. It is recommended by readers and experts. Read more about the book.
Read more on nutrients and depression
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Comments (1)
I have suffered from depression for over 8 years. I had been put on lexapro for a while, but did not like it. I had been reading about using vitamin and mineral supplements to help depression and have been doing so for the past 2 years. It changed my life. the specific supplements that make the largest difference is the vitamin B complex and magnesium. I take B-Right and Magnesium Optimizer by Jarrow formulas. www.VitaminLab.Net has the best prices on these products and so I use them, but you can get them at any health food store or vitamin shoppe.
wishing everyone happiness and freedom from depression:)
Posted by DEllis | January 7, 2010 12:50 AM | Reply